Thermo Scientific Vanquish UHPLC System

Thermo Fisher Scientific Vanquish

This listing is for the Thermo Scientific Vanquish UHPLC Sytem

The unit is in full working condition and is ready for immediate use

Overview: Thermo Scientific Vanquish UHPLC Systems

1. Autosampler

Purpose: Introduces the sample into the mobile phase stream automatically.

Picks up sample from vials, plates, or tubes

Injects with high precision (often nL to µL volume range

2.Pump Module

Purpose: Delivers the mobile phase (solvent) through the system at high pressure.

Binary pump: Mixes two solvents at high pressure. Ideal for fast gradients.

Quaternary pump: Mixes up to four solvents at low pressure. More flexible, but slower gradients.

Controls flow rate (e.g., 0.001–5.000 mL/min)

Enables gradient elution (changing solvent composition over time

3.Detector Module (x2)

Purpose: Detects and measures analytes as they elute from the column.

Diode Array Detector (DAD/UV-Vis) – most common; detects UV-absorbing compounds

Fluorescence Detector – for fluorescent compounds

Charged Aerosol Detector (CAD) – universal detection for non-UV compounds

Refractive Index Detector – for sugars, polymers

MS (Mass Spectrometer) – advanced, highly sensitive detection

Thermo Fisher’s Vanquish platform includes several variants tailored to different analytical needs—from routine HPLC to ultra-high-throughput and low-flow LC–MS workflows:

Vanquish Flex UHPLC: Offers flexible HPLC/UHPLC method development and operates up to 1000 bar. It supports binary, quaternary, and dual pumps, plus intelligent tools like solvent monitoring and optional touchscreen interface.

Vanquish Horizon UHPLC: Built for maximum performance, offering ultra-high pressure (up to 1500 bar), ultra-low gradient delay volume, biocompatible flow paths, and exceptional retention time stability and detector sensitivity.

Vanquish Neo UHPLC: Designed for next-gen low-flow LC‑MS workflows (nano‑ to micro‑flow), delivering high‑sensitivity, high‑robustness separations.

Vanquish Analytical Purification LC: Specialized for precise fractionation—high pressure (700–1500 bar), customizable flow (up to 10 mL/min), integrated fraction collector, multimodal detection, and advanced automation.

Key Features Across the Platform

Modular Design: Choose components (pumps, samplers, detectors, thermostatting units) to configure a tailored system. Most models offer biocompatible flow paths and Viper fingertight fittings for low dead‑volume, tool‑free setup.

Temperature Control: High-performance column compartments with active/passive heating, pre‑heating, and post‑column cooling to manage frictional heating and improve reproducibility.
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Detection Options: Available detectors include Diode Array (with LightPipe optics for superb sensitivity), Charged Aerosol Detector (CAD) for near‑universal detection, fluorescence, multi‑wavelength, refractive index, and mass spectrometry detection.



Software Integration: Fully compatible with Chromeleon CDS (with SII for streamlined MS integration), plus Xcalibur and TraceFinder for LC‑MS workflows.

MS Integration: Vanquish systems interface seamlessly with Thermo MS platforms—Triple Quadrupole and Orbitrap—for sensitive, accurate mass analysis.

Operational ROI: Thermo highlights reduced unplanned repairs, improved productivity, and net-zero ambitions through renewable-powered manufacturing.